What are SARMs?
Selective androgen receptor modulators (SARMs) are therapeutic agents with properties similar to steroids but with weaker androgenic properties. The main difference between SARMs and steroids is that SARMs are highly target and selective in their mechanism of action. SARMs have a specific affinity for certain tissues, such as muscle and bone, but not for others such as the prostate, liver, and brain. They also do not convert into unwanted substances, such as DHT and estrogen, which can cause side effects. This makes it impossible to experience side effects like steroids when using SARM, such as male macromastia, water retention, hair loss, etc.
What does SARMs do?
SARMs increase protein synthesis, which promotes muscle growth. As we age, our endurance, strength, and skeletal muscle mass decline due to the gradual loss of type 2 muscle fibers. This severely limits our athletic performance. In this androgen-deficient population, skeletal muscle mass and muscle strength will be significantly improve with SARM.
SARMs are a new performance-enhancing compound that is shaking up the fitness industry. They can promote muscle growth, fat loss, and even cardiovascular endurance. SARMs connect to the same androgen receptors as steroids (such as vigorous supplementation and testosterone) but can minimize the drawbacks of traditional steroids and hormone-pro side effects. SARMs can help increase muscle mass while helping you reduce body fat and improve athletic performance beyond your imagination, which in muscle pharmacology is a huge breakthrough.
What types of SARMs are there?
In this article we will mainly introduce you RAD 140 and MK 677. RAD 140 is a myogenic new SARM for building muscle and boosting strength. MK 677 is an orally effective growth hormone pro-secretor, a potent non-peptide hunger receptor agonist that promotes increased lean body mass as well as IGF-1 serum concentrations.
also known as testolone, is an exciting SARM, and the most popular SARM, with increased muscle mass, libido, and strength when used.
RAD 140 is more popular among bodybuilders as a new investigational drug, which is a selective androgen receptor modulator. It can bind to androgen receptors in different parts of the body. Normally, these receptors have interactions with androgens.
SARMS and testosterone have similar effects because they act on the same receptor. The anabolic rate of RAD140 has been report to be an incredible 90:1. The ratio for testosterone is 100:100. This means that RAD140 is almost as anabolic, but does not have nearly the androgenic effects of true testosterone. SARMS targets muscle, bone, and liver. It mainly targets muscle and bone tissue. It has little effect on the prostate and other organs. Because of this, some researchers believe that SARMs have the potential to treat hormone-related or muscle-wasting disorders compared to existing treatments.
RAD140 currently has a potential role in increasing muscle mass, fighting breast cancer, and protecting brain cells. Despite the lack of safety studies on humans, bodybuilders use RAD140 to build strength and endurance.
In terms of the benefits of RAD 140, there are currently seven main benefits collected in initial studies and user-report comments.
1) RAD 140 helps increase muscle mass
The primary benefit of RAD 140 supplementation is the ability to increase lean muscle tissue without increasing fat. And with RAD 140, there are no adverse side effects that are traditionally associate with testosterone.
2) RAD 140 can improve speed and endurance during high-intensity training
Reports of increased speed and endurance during workouts are everywhere when using the Testolone supplement. In addition, high-intensity training and interval training can be optimize every time due to their ability to increase muscle tissue and reduce fat.
3) RAD 140 has a stronger anabolic effect than testosterone
Similar to other SARMs, such as LGD4033 or S4, RAD 140 interacts with hormone receptors in muscle and bone tissue in the same manner as high-dose testosterone, all without the estrogenic side effects caused by anabolic steroids.
4) RAD 140 can reduce the side effects of testosterone
Testosterone does not appear to have the side effects of anabolic steroids on reproductive organs. Preliminary studies in mice have found that low doses of RAD 140 are required to stimulate muscle growth without affecting prostate weight. This means that RAD 140 can selectively stimulate muscle and bone growth while reducing the effects on sexual tissues.
5) RAD 140 can help reduce weight by increasing fat loss
RAD 140 indirectly reduces body fat by increasing muscle and bone cells, which are more expensive to maintain metabolically than fat cells. By increasing muscle mass, an increase in metabolism can be seen, which makes it easier to lose weight.
6) RAD 140 is being trialed in quality breast cancer
RAD 140 was discovered and currently has the pharmaceutical company Radius developing it, and in vitro studies completed in 2017 showed that RAD 140 inhibits the growth of AR/ER+ breast cancer cells. The results of these studies support further investigation of RAD 140 as a breast cancer treatment and present the first human clinical trial.
7) RAD 140 is thought to have a neuroprotective effect on brain health in neurological disorders
As testosterone levels decline in men, the risk of disease in androgen-responsive tissues (including the brain) increases, implying the development of neurodegenerative diseases such as Alzheimer’s disease. However, treating AR disease with testosterone may increase the risk of developing prostate cancer. Recent studies suggest that RAD 140 may be as effective as testosterone in reducing cell death, with no side effects on the prostate.
For the side effects of RAD 140, testolone appears to be very safe. There have been no reports of prostate enlargement, elevated liver enzymes, estrogen conversion, or hair loss. But eradicating online users may cause male pattern baldness and sexual and altered mood disorders. rad 140 may suppress testosterone, depression, and fatigue. There is an increase risk of side effects if high doses are use over a long period.
produce by Reverse Pharmacology is an orally administer substance that promotes the secretion of growth hormone and is an exciting compound that is rapidly gaining popularity. It was originally use to deal with health problems such as osteoporosis, obesity, and muscle wasting, but MK 677 has been shown to promote an increase in lean body mass as well as IGF-1 serum concentrations.MK 677 is a growth hormone pro-secretor, and what makes it special is that it significantly increases growth hormone levels in the body.
MK 677 is a flexible growth hormone. The breakdown of MK 677 has the following classic effects.
- Increase fat oxidation to enhance fat loss efficiency. Bodybuilding and muscle growth MK 677 will boost IGF (insulin-like growth factor) levels, so users have achieved the effect of quickly boosting muscle mass without affecting fat mass by increasing the number of muscle cells.
- Faster healing of ligaments, tendons, bones, and old injuries. Bone density decreases with age, but some young people and children also experience this due to certain diseases. MK 677 boosts growth hormone production, which then stimulates bone renewal, which can increase bone density. This is why it can help strengthen bones.
- Control and balance cortisol to help treat growth hormone deficiency Some children and adults suffer from growth hormone deficiency. And MK 677 adds the IGF-1 hormone, so it can help people to compensate for this deficiency. This product is different becauseit is safe for both children and adults. It does not increase cortisol, thyroid-stimulating hormone, glucose, or prolactin levels.
- Improved sleep quality and cognitive function. When falling asleep, MK 677 increases the duration of REM, the stage involving deep sleep and thought to process. During sleep, our body naturally secretes growth hormones. Thanks to this hormone, we can recover our memory and learning ability during sleep.
- A larger boost in appetite (effective in some people). MK 677 increases appetite and therefore calorie intake. Most of the calories are use to build muscle, so your body is essentially forced to use fat reserves for metabolism.
- Build muscle mass and size gain. It has been said that MK 677 is the “genie of youth” and that it has the power to rejuvenate. MK 677 is know to help build lean body mass and bone density. As we age, muscle mass begins to decline and it is difficult to build new muscle here. Therefore, older people or those who have suffered serious injuries will take MK 677 to build up their strength.
However, MK 677 has certain disadvantages. the main side effect of MK 677 is water retention, and long-term use of the body is accompanied by a certain amount of water storage. Sometimes it can be accompanied by finger pain due to high growth hormone levels. Some people may experience frequent hunger pangs. MK 677 may also slightly affect lactogen in a small number of people. It is not suitable for people with eating disorders, such as binge eating behavior and poor eating habits.
is a tightly reconstitute chemical structure of LGD-4033, a drug that acts as a SARM with good oral bioavailability. LGD-3303 is a selective agonist of the androgen receptor, producing functional selectivity through the effective dissociation of anabolic and androgenic effects. It can significantly increase muscle strength and the ability to prevent muscle atrophy. Although it can be argue that other products can achieve the same effect, it is clear that LGD-3303 is more effective.
- LGD-3303 can provide some potential benefits, first of all, LGD-3303 can provide effective androgenic effects without affecting the androgenic organs, which is a very big benefit. The side effects of SARM as a substitute for steroids as a product are also very small compare to the previous ones.
- LGD-3303 helps to increase muscle mass and bone density. This is a very important feature for bodybuilding sports transportation.
- LGD-3303 is also thought to have the ability to improve metabolic effects. This is significant in that those who want to lose weight can use SARM to help them experiment with their weight loss goals. However, LGD-3303 is important along with other equally effective SARMs and a sound exercise regimen.
Compared to LGD-4033, LGD-3303 has fewer side effects such as no estrogen conversion and less suppression.
SARMS is not strictly consider a drug, it is a substance that sits between a supplement and a drug and is consider a bridging compound in bodybuilding. It produces similar results to steroids but does not produce the same side effects. All SARMS do not suppress internal organs, have no hepatotoxicity, and are not trans-female. Therefore, these products should have good prospects for application.